抗菌药物去阶梯/停药核对工具
按培养结果、稳定性和源控制判断收窄、序贯或停药条件。
去阶梯是抗菌药物管理核心流程，目标是维持疗效同时减少毒性、艰难梭菌感染和耐药选择压力。
注意事项：停药或降阶梯必须由主管医师结合病情、感染灶、病原学和本院制度决定。
参考来源
- Tamma PD, Aitken SL, Bonomo RA, et al. Infectious Diseases Society of America 2024 guidance on the treatment of antimicrobial-resistant Gram-negative infections. Clin Infect Dis. 2024.
- Rybak MJ, Le J, Lodise TP, et al. Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: revised consensus guideline. Am J Health Syst Pharm. 2020;77(11):835-864.
- Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52(3):e18-e55.
- Global guideline for the diagnosis and management of candidiasis: an initiative of ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis. 2025.
- Patterson TF, Thompson GR 3rd, Denning DW, et al. Practice guidelines for aspergillosis. Clin Infect Dis. 2016;63(4):e1-e60. 注：IDSA 2026实体器官移植受者曲霉预防指南仅用于预防场景。
- Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181-1247.
- Kalil AC, Metersky ML, Klompas M, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia. Clin Infect Dis. 2016;63(5):e61-e111.
- DailyMed. U.S. National Library of Medicine. FDA label information for marketed antimicrobial drugs. https://dailymed.nlm.nih.gov/